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KMID : 0620920190510080094
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Experimental & Molecular Medicine
2019 Volume.51 No. 8 p.94 ~ p.94
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Exosomal PD-L1 promotes tumor growth through immune escape in non-small cell lung cancer
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Kim Dong-Ha
Kim Hyeong-Ryul
Choi Yun-Jung
Kim Seon-Ye
Lee Jung-Eun
Sung Ki-Jung
Sung Young-Hoon
Pack Chan-Gi
Jung Min-Kyo
Han Buhm
Kim Kun-Hee
Kim Woo-Sung
Nam Soo-Jeong
Choi Chang-Min
Yun Mi-Yong
Lee Jae-Cheol
Rho Jin-Kyung
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Abstract
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Programmed cell death protein-1/programmed cell death ligand-1 (PD-1/PD-L1) pathway blockade is a promising new cancer therapy. Although PD-1/PD-L1 treatment has yielded clinical benefits in several types of cancer, further studies are required to clarify predictive biomarkers for drug efficacy and to understand the fundamental mechanism of PD-1/PD-L1 interaction between host and tumor cells. Here, we show that exosomes derived from lung cancer cells express PD-L1 and play a role in immune escape by reducing T-cell activity and promoting tumor growth. The abundance of PD-L1 on exosomes represented the quantity of PD-L1 expression on cell surfaces. Exosomes containing PD-L1 inhibited interferon-gamma (IFN-γ) secretion by Jurkat T cells. IFN-γ secretion was restored by PD-L1 knockout or masking on the exosomes. Both forced expression of PD-L1 on cells without PD-L1 and treatment with exosomes containing PD-L1 enhanced tumor growth in vivo. PD-L1 was present on exosomes isolated from the plasma of patients with non-small cell lung cancer, and its abundance in exosomes was correlated with PD-L1 positivity in tumor tissues. Exosomes can impair immune functions by reducing cytokine production and inducing apoptosis in CD8+ T cells. Our findings indicate that tumor-derived exosomes expressing PD-L1 may be an important mediator of tumor immune escape.
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KEYWORD
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Cancer microenvironment, Immunoediting
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